Beta-Adrenergic Antagonists Attenuate Somatic and Aversive Signs of Opiate Withdrawal
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چکیده
منابع مشابه
Disruption of the CRF/CRF1 Receptor Stress System Exacerbates the Somatic Signs of Opiate Withdrawal
Escape from the extremely stressful opiate withdrawal syndrome may motivate opiate seeking and taking. The corticotropin-releasing factor receptor-1 (CRF1) pathway mediates behavioral and endocrine responses to stress. Here, we report that genetic inactivation (CRF1-/-) as well as pharmacological antagonism of the CRF/CRF1 receptor pathway increased and prolonged the somatic expression of opiat...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 1993
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.1993.66